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Miscellaneous

COX-2 inhibitors

Pages 1465-1468 | Published online: 02 Mar 2005
 

Abstract

These three applications claim 4-fluoroalkyl-6-(4-alkylsulfonyl)phenylpyrimidine derivatives that are selective COX-2 inhibitors. The presence of an additional 5-alkyl substituent markedly attenuates their potency but both 4-alkylamino and 4-alkoxy substituted compounds are potent and selective COX-2 inhibitors in the absence of the 5-substituent.

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