Chemokine CCR5 antagonists incorporating a 4-aminopiperidine scaffold

Abstract

Novel 4-aminopiperidine derivatives with potent chemokine CCR5 antagonist activity are claimed. The claimed compounds contain a second cyclic amine (piperazine or piperidine) ring and are generally characterised by the presence of at least one sulfonyl group. The compounds are indicated to be useful in treating HIV infection, autoimmune and inflammatory diseases.

• CCR5 antagonist
• chemokine
• HIV-1
• inflammation
• macrophage inflammatory protein (MIP)-1α
• RANTES