The use of indole-3-acetic acids as CRTH2 receptor antagonists

Abstract

Two applications describe 1-heteroaryl-indole-3-acetic acid derivatives as CRTH2 receptor antagonists and claim their use in providing methods of treating asthma, chronic obstructive pulmonary disease and rhinitis. One application claims the use of quinolinyl and quinoxalinyl-indole-3-acetic acids originally described in 1974, while the second claims novel benzothiazolyl and pyrimdinyl-indole-3-acetic acids.

• allergic rhinitis
• asthma
• chronic obstructive pulmonary disease (COPD)
• CRTH2
• indole-3-acetic acid
• prostaglandin (PG)D₂
• prostaglandin D (DP) receptor