Inhibitors of sodium-dependent phosphate transport

Abstract

Phosphate retention has been shown to play a major role in the progression of renal failure and induction of uremic bone disease and secondary hyperparathyroidism. Inhibiting intestinal phosphate absorption by inhibition of the sodium-dependent phosphate transporter (NaPi-3b^‡) by a small molecule would be a desirable method to control serum phosphate levels in patients with chronic renal disease or undergoing dialysis. In this review the progress in the identification of such an agent is discussed.

• NaPi-3b
• phosphonoformic acid
• renal failure
• sevelamer
• sodium-dependent phosphate transporter
• uremic bone disease