67
Views
33
CrossRef citations to date
0
Altmetric
Review

Recent advances in the cannabinoids

Pages 1435-1452 | Published online: 25 Feb 2005
 

Abstract

This review highlights advances made in cannabinoid chemistry over the time period August 2002 – June 2004. Particular emphasis is placed on new ligands for the CB1 and CB2 receptors. CB1 receptor antagonists have been a prominent area of research for many pharmaceutical companies. Sanofi’s CB1 receptor antagonist rimonabant has now generated clinical data demonstrating its efficacy for both obesity and smoking cessation in human subjects. Recent data showing the effects of CB2 agonists for pain in preclinical animal models has been accompanied by the reports from many laboratories disclosing selective CB2 agonists for the treatment of pain and other indications. The further progression of cannabinoid receptor agonists and antagonists into clinical trials will serve to determine the effectiveness of such compounds as therapeutics in the treatment of human diseases and disorders.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.