MMP-12 inhibitors

Abstract

Novel N-arylalkyl 5-hydantoin acetamide derivatives are claimed. These compounds are shown to be potent matrix metalloproteinase-12 (MMP-12) inhibitors, and their use for the treatment of asthma and chronic obstructive pulmonary disease (COPD) is claimed. This application is one of a large series of applications claiming closely-related compounds as inhibitors of certain MMPs.

• asthma
• chronic obstructive pulmonary disease (COPD)
• elastase
• emphysema
• matrix metalloproteinase (MMP)
• MMP-9
• MMP-12