Imidazole-4-carboxamide derivatives as inhibitors of adenosine deaminase

Abstract

Novel imidazole-4-carboxamide derivatives endowed with adenosine deaminase (ADA) inhibitory activity are claimed. The claimed compounds present a second heterocycle (benzoxazole or benzothiazole) linked through a spacer to the N-1 nitrogen of imidazole. Two of the claimed compounds were tested as ADA inhibitors on the human recombinant enzyme and were shown to inhibit ADA activity with a median inhibitory concentration value < 20 nM.

• adenosine deaminase (ADA)
• ADA inhibitor
• imidazole-4-carboxamide derivative