Apolipoproteins and apolipoprotein agonists for the treatment of ischaemia/reperfusion injury

Abstract

The use of agents and methods for the prevention, reduction or treatment of ischaemia/reperfusion (I/R) injury is claimed. The claimed agents can be any apolipoprotein, an apolipoprotein variant or fragment, paraoxonase, or lecithin:cholesterol acyltransferase. The agents are indicated to be useful in any condition where protection from, or treatment of, I/R injury is needed.

• apolipoprotein
• high-density lipoprotein
• ischaemia/reperfusion
• lecithin:cholesterol acyltransferase
• oxygen radical
• paraoxonase
• TNF-α