Cystic fibrosis transmembrane regulator (CFTR) modulators

Abstract

Novel 5-aryl-3-phenylpyrazole derivatives and their use as ATP-binding cassette regulators for the treatment of diverse diseases are claimed. The claimed compounds are shown to activate the defective chloride channels associated with the genetic disease cystic fibrosis. Accordingly, such pyrazoles may be of particular utility in the treatment of cystic fibrosis by improving the defective mucociliary clearance that gives rise to the repeated lung infections.

• ABC transporter
• cystic fibrosis transmembrane regulator (CFTR)
• chloride channel opener
• cystic fibrosis
• pyrazole