New insights into the development of ATP-sensitive potassium channel openers

Bernard PirotteNatural and Synthetic Drugs Research Center Laboratoire de Chimie Pharmaceutique, Université de Liège, 1, Avenue de l’Hôpital, B-4000 LiègeBelgiumTel: +32 4 366 43 65; Fax: +32 4 366 43 62; E-mail: [email protected]

Pascal de TullioLaboratoire de Pharmacodynamie et de Thérapeutique Université Libre de Bruxelles, 808, route de Lennik, B-1070, BruxellesBelgium

Marie-Hélène AntoineNatural and Synthetic Drugs Research Center Laboratoire de Chimie Pharmaceutique, Université de Liège, 1, Avenue de l’Hôpital, B-4000 LiègeBelgiumTel: +32 4 366 43 65; Fax: +32 4 366 43 62; E-mail: [email protected]

Sophie SebilleLaboratoire de Pharmacodynamie et de Thérapeutique Université Libre de Bruxelles, 808, route de Lennik, B-1070, BruxellesBelgium

Xavier FlorenceNatural and Synthetic Drugs Research Center Laboratoire de Chimie Pharmaceutique, Université de Liège, 1, Avenue de l’Hôpital, B-4000 LiègeBelgiumTel: +32 4 366 43 65; Fax: +32 4 366 43 62; E-mail: [email protected]

Philippe LebrunLaboratoire de Pharmacodynamie et de Thérapeutique Université Libre de Bruxelles, 808, route de Lennik, B-1070, BruxellesBelgium

Abstract

ATP-sensitive potassium channel openers are expected to be valuable drugs for the treatment of a wide variety of pathologies. However, their clinical interest depends mainly on their tissue selectivity, which is linked to their affinity for a specific ATP-sensitive potassium (K_ATP) channel subtype. Hypertension was the first indication for K_ATP channel openers currently on the market. Recent progress in the synthesis of tissue-selective compounds led to the discovery of potential candidates for the management (prevention and/or treatment) of several pathological states such as Type 1 or Type 2 diabetes, obesity, urinary incontinence and congestive heart failure. The present report focuses on patent applications introduced between 2001 – 2004, describing original K_ATP channel openers.

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New insights into the development of ATP-sensitive potassium channel openers

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