Compounds and methods for inhibiting mitotic progression

Abstract

In this application, Millennium claims pyrimidoazepines, in particular N-aryl-(7-phenyl-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)-amino derivatives, as inhibitors of Aurora kinases. The claimed compounds display good potency (in most cases < 100 nM) in the enzymatic bioassay for Aurora-A inhibition and are indicated to be useful for the treatment of cancer and other proliferative disorders.

Keywords::

• antimitotic
• Aurora kinase
• protein kinase inhibitor

Patent details

• Title Compounds and methods for inhibiting mitotic progression

• Assignee Millennium Pharmaceuticals, Inc.

• Inventors Claiborne CF, Payne LJ, Boyce, RJ et al.

• Priority date 08/10/05

• Filing date 12/05/05

• Publication date 17/11/05

• Publication number US20050256102