4-Arylpiperidine derivatives and uses thereof for preparing a medicament for the treatment of CNS disorders

Abstract

A novel series of 4-arylpiperidines and their salts, as well as their use in the treatment of CNS disorders, that is, depression, are disclosed. These compounds function as serotonin transporter (SERT) inhibitors and demonstrate significant activity and selectivity for SERT versus other receptors and monoamine transporters.

Keywords::

• 4-arylpiperidine
• depression
• serotonin
• SRI

Patent Details

• Title 4-Arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of CNS disorders.

• Assignee University of Pisa.

• Inventors Nencetti, S, Lapucci A, Orlandini E, Balsamo A, Mazzoni MR.

• Priority date 08/04/2005

• Filing date 06/04/2006

• Publication date 12/10/2006

• Publication no. WO2006106432