Inhibitors of Akt Activity

Abstract

Imidazo[4,5-c]pyridine analogs with Akt (PKB) kinase antagonist activity are claimed. The compounds contain a 4-amino-1,2,5-oxadiazole substituent at the 2-position of the ring system with an alkyne substituent at the 4-position, and diverse functionality at the 6-position. The compounds are indicated to be useful in the treatment of cancer and arthritis.

Keywords::

• 4-amino-1,2,5-oxadiazole
• Akt antagonist
• imidazo[4,5-c]pyridine
• PKB

Patent Details

• Title Inhibitors of Akt activity.

• Assignee SmithKline Beecham Corporation.

• Inventors Heerding DA, Rouse MB, Seefeld MA.

• Priority date 20/04/05.

• Filing date 20/04/05.

• Publication date 26/10/06.

• Publication no. WO2006/113837.