Coeliac disease. From A – Z

Abstract

Coeliac disease is a common malabsorptive disorder of the small intestine characterised by villous atrophy and crypts hyperplasia. It is due to a permanent intolerance to dietary gluten that advances to immunologically dependent inflammatory reaction in genetically susceptible individuals. In recent years, with enhanced diagnostic capacity, the actual epidemiology and diversity of the condition has become increasingly apparent. Diagnosis relies on histological identification of gluten sensitive enteropathy as well as serological markers and clinical presentations. The treatment of coeliac disease consists of dietary programme, counselling, education and support during periodic reviews. A variety of complications of the condition have been recognised that may cause significant morbidity and premature mortality. Early diagnosis and compliance to treatment recommendations can effectively avoid these complications.

Keywords::

• coeliac disease
• coeliac sprue
• gluten-sensitive enteropathy

Notes