Efflux pump inhibitors in bacteria

Abstract

The efficacy of antibiotherapy of infectious diseases is strongly compromised by the advent and spread of antibiotic resistance. Active efflux of cytotoxic drugs mediated by multi-drug transporters is the basis of multi-drug resistance in prokaryotic cells. Thus, inhibition of efflux pumps appears to be a promising strategy to combat multi-drug resistance pathogens. Different classes of inhibitors structurally unrelated have been patented in the last decade.

Keywords::

• antibiotics
• efflux pumps
• inhibitors
• multi-drug resistance