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Summary
Novelty: Pyrimidinedione derivatives which are claimed to be effective in the treatment of cardiac arrhythmias are disclosed.
Biology: Myocardial action potential duration time (APD75) effects are measured in an assay using hybrid adult dog heart as described previously (results are tabulated).
Chemistry: The synthesis is by standard techniques. Fifteen compounds are exemplified by synthesis. 1,3-Dimethyl-6-[4-(2-hydroxy-4-phenylbutyl)piperazin-1-yl]-2,4-(1H,3H)-pyrimidinedione hydrochloride is the preferred compound.
Structure: