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Anti-Inflammatory, Anti-Allergic, Respiratory & GI Agents

Patent Evaluation: Indole Derivatives as Anti-Allergic and Anti-Inflammatory Agents

Pages 1602-1604 | Published online: 02 Mar 2011
 

Summary

Novelty: Novel indoles with lipoxygenase inhibitory activity are disclosed.

Biology: No detailed biological data are provided. The compounds are stated to have IC50 values in the range 0.1-30μM.

Chemistry: Syntheses are described in twenty-nine examples and ten specifically claimed compounds are illustrated, one of which is 1-(3-methoxybenzyl)-5-(2-quinolylmethoxy)-indole.

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