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Summary
Novelty: Novel sulphonic acid stilbenes are claimed to be useful for the treatment of HIV, HSV and CMV infections.
Biology: In vitro antiviral activity was assessed against HIV-1 infected human T-cell line JM. 4,4-Di-isothiocyanatodihydrostilbene-2,2-disulphonic acid (DIDS) was the most active compound, giving 93.6% control at 50μM; this was determined by following the dose-dependent inhibition of p24 viral core antigen.
Chemistry: The preparation of the novel compounds is described briefly. Three compounds are specifically claimed, including DIDS.
Structure: 