3
Views
0
CrossRef citations to date
0
Altmetric
Antimicrobials

Patent Evaluation: Novel Monoclonal Antibodies for Putative HCV Regions

Pages 1857-1858 | Published online: 02 Mar 2011
 

Summary

Novelty: A panel of highly specific and novel monoclonal antibodies for putative HCV envelope regions is disclosed. It provides a diagnostic tool for the acute stage of hepatitis C infections.

Biology: A sample with putative HCV antigens is contacted with a poly- or monoclonal anti-HCV envelope region antibody or fragment and incubated. Treatment with an indicator specific for HCV antigen attached to a compound generating a measurable signal enables the amount of HCV antigen to be determined. The compounds can be chromagens, enzymes, luminescent and chemiluminescent compounds, radioactive elements and direct visual labels. Three examples of assays are disclosed. Various body fluids can be used as test samples.

Chemistry: Synthetic peptides were synthesized by standard techniques. The amino acid sequence of the putative ENV domain of the HCV genome 380-486 was determined by standard techniques.

Structure:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.