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Summary
Novelty: A dietary treatment of the symptoms of pubertal premenstrual syndrome (PMS) is disclosed, comprising linolenic acids, calcium and iron sources, and optionally magnesium, vitamin B6 and other vitamins. The linolenic acids are thought to promote prostaglandin synthesis, hence alleviating PMS; the other constituents are present to replace excess losses during the pubertal period.
Biology: A small clinical trial comprising pubescent females took an exemplified formulation of the claim daily for two months, and are stated to have shown improvements in daily energy, PMS symptoms and skin condition. However, no specific data are provided.
Chemistry: Linolenic acid is provided as the native acid (Merck Index 5383) and/or as γ-linolenic acid (Merck Index 5384) at about 0.1 mg/day in the form of Evening Primrose or Borage oils. Calcium is presented as the gluconate, carbonate or dicalcium phosphate; iron as ferrous sulphate, gluconate or fumarate. Example formulations are provided, incorporating the diverse constituents at their recommended daily intake levels or below.