Patent Evaluation: Free Radical Scavengers for Pulmonary Disease Therapy

Summary

Novelty: The treatment of acute and chronic respiratory distress syndromes, such as ARDS or IRDS, using thiazolidine-4-carboxylates or esters of glutathione is claimed. The non-cysteine substrate is said to maintain normal glutathione levels and to be effectively distributed.

Biology: Four case studies are presented in which physiological and clinical characteristics at the beginning and end of the treatment are presented. L-2-oxothiazolidine-4-carboxylate is given iv to 15 mg/kg tid.

Structure: