Summary
Novelty: Leustroducsins A, B and C have been isolated from a new non-pigmented strain of Streptomyces platensis. They appear to be distinct from similar pyranone derivatives isolated from S. platensis SAM-0654 or phospholine produced by S. hygroscopicus.
Biology: These leustroducsins have been shown to stimulate GM-CSF and G-CSF production by KM-102 cells and nerve growth factor production by L-M cells in vitro. A direct antifungal effect has been demonstrated quantitatively in vitro using Trichophyton mentagrophytes. Based on these limited observations, claimed are made for utility in the treatment or prophylaxis of adverse reactions resulting from cancer chemotherapy or radiotherapy, infections, cancer, cerebral dysfunction and fungal infections.
Structure: