Summary
Novelty: Novel peptides with affinity for sites of vascular injury are disclosed. These peptides, when labelled with radioactive isotopes such as [125I], are potentially useful for the detection and mapping of vascular injury. The peptides may also be useful for the prevention or treatment of vascular damage.
Biology: The ability of the peptides to target the sites of vascular injury is demonstrated using rabbit models. Representative results are described.
Chemistry: Fourteen peptides are synthesized using standard solid-phase peptide synthesis methodology. Selected derivatives are labelled with [125I] or [99Tc] using standard methods. Eight peptide sequences are specifically claimed.