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Summary
Novelty: Novel methods for the modulation of blood pressure, using transforming growth factor-β (TGF-β) and TGF-β antagonists are disclosed. The TGFs are potentially useful as antihypertensive agents.
Biology: In vivo cynomolgous monkey studies are described. Blood pressure is monitored via arterial catheratization. Recombinant mature TGF-β1, isolated and transferred from Chinese hamster ovary cells, induces significant and sustained decreases in BP on injection of rTGF-β1 in doses of 0.51 mg/kg. No significant fluctuation in BP is observed in the control.
Chemistry: Transforming growth factors may be obtained from natural sources. They can also be produced via conventional recombinant DNA or chemical techniques. Preparative references are presented.