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Summary
Novelty: Novel biphenyl carboxylic acid derivatives are disclosed. These compounds are claimed to be aldose reductase inhibitors and are potentially useful for the treatment of diabetic complications such as cataract, retinal diseases, neuropathy, corneal and disorders diabetic ureitis.
Biology: The disclosed compounds were evaluated for inhibition of aldose reductase and for suppression of sorbitol accumulation in lens and sciatic nerves. The specified compound provided 63% inhibition of aldose reductase at a concentration of 0.1γ. At 2.5γ, sorbitol accumulation (lens) was inhibited by 85%.
Chemistry: 2,2′-Dimethoxy-5,5′-bis(3-carboxypropyl)biphenyl is one of three specifically claimed compounds.
Structure: 