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Summary
Novelty: A novel method for the treatment of bone wasting diseases using progestin therapy is disclosed. The method is claimed to have particular utility for the treatment of post-menopausal osteoporosis.
Biology: In vitro osteoblast stimulating activity is described. Preferred compounds exhibited ≥ 20% stimulation (compared with control) of 3H-thymidine incorporation in MC3T3-E1 osteoblast cells.
Chemistry: Norethindrone, norethindrone acetate, chlormadionone acetate, megestrol acetate, norethynodrel, medroxyprogesterone acetate and progesterone are specifically claimed in relation to the use claim. Preparative details are not presented.
Structure: 