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Summary
Novelty: Novel acridines are disclosed. These compounds are claimed to exert an anticancer effect through interactions with topoisomerase II and may be particularly useful for the treatment of small cell lung cancer, testicular cancer, lymphomas and leukaemias.
Biology: In vitro topoisomerase II activity was evaluated, significant activity was observed at 100μM. In vitro inhibition of small cell lung cancer cell line N417A (IC50 = 0.4μM) and mouse leukaemia cell line L1210 are also described.
Chemistry: 3-Chloro-10-(4-hydroxy-3,5-dimethoxybenzyl)-9,10-dihydroacridin-9-one is one of twelve specifically claimed compounds.
Structure: 