Patent Evaluation: Thioxoheterocycles as 5-lipoxygenase Inhibitors

Summary

Novelty: Novel thioxoheterocycles and their preparation are disclosed. Also described are pharmaceutical compositions containing the novel compounds and their use in the production of medicaments for use in a leukotriene mediated disease or medical condition.

Biology: The thioxoheterocycles are inhibitors of the enzyme 5-LPO. The effects of this inhibition are demonstrated by standard procedures. No other biological data are provided.

Chemistry: Three specifically claimed compounds illustrate the preparation of novel compounds and intermediates. A preferred class of novel compounds are specifically claimed including 4-[5-fluoro-3-(1-methyl-2-thioxo-1,2-dihydroquinolin-6-ylmethoxy)phenyl]-4-meth-oxytetrahydropyran.

Chemistry: Three specifically claimed compounds illustrate the preparation of novel compounds and intermediates. A preferred class of novel compounds are specifically claimed including 4-[5-fluoro-3-(1-methyl-2-thioxo-1,2-dihydroquinolin-6-ylmethoxy)phenyl]-4-meth-oxytetrahydropyran.

Structure: