5
Views
0
CrossRef citations to date
0
Altmetric
Antimicrobials

Patent Evaluation: Novel Compositions for the Treatment of HIV Infections

Pages 659-660 | Published online: 02 Mar 2011
 

Summary

Novelty: Novel 5-thiolated oligo- and polynucleotide compositions which are potentially useful for treating HIV infections are disclosed. The nucleotides may be therapeutically effective agents for inhibiting HIV-infections.

Biology: The anti-HIV activity of 5-thiolated oligo- and polynucleotides were evaluted in vivo against Hg human lymphocytes and human peripheral blood mononuclear cells (PBM cells). Although all compositions showed anti-HIV activity, the most active include mercaptopolydeoxy-cytidylate (MPdC) in PBM cells (EC50 = 2.42 g/ml).

Chemistry: The synthesis of one compound is described with four compounds exemplified. All compounds are prepared by conventional synthetic or enzymatic methods. Six compounds are specifically claimed including 5-mercaptopolycytidylic acid.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.