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Summary
Novelty: Substituted arylsulphonamides and benzamides said to have anti-arrhythmic activity are disclosed. They are proposed to be of therapeutic value as class III anti-arrhythmic agents.
Biology: An in vitro study utilizing canine Purkinje fibres is described. An increase in action potential duration at −60 mV (APD−60). without a significant change in Vmax, was observed. In vivo canine studies showed an increase in ERP without a significant decrease of CT. It is proposed that the results of these studies are indicative of class III anti-arrhythmic activity.
Chemistry: N-methyl-N-[2-methyl(1-methyl-1H-benzimidazol-2-yl)amino]ethyl-4-[(methyl-sulphonyl)amino]benzenesulphonamide is one of nineteen compounds specifically claimed. Preparative details using standard techniques are presented.