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Cardiovascular Agents (Including Blood Products)

Patent Evaluation: Novel Indolines as Vasopressors

Pages 737-738 | Published online: 02 Mar 2011
 

Summary

Novelty: N-Sulphonyl indoline derivatives are disclosed and are stated to be vasopressors. The compounds are proposed for treatment of hypertension and are also maintained to be intermediates in the preparation of active CNS agents.

Biology: No specific biological data are presented. The therapeutic dose is stated to be 0.01–50 mg/kg and various compositions are described.

Chemistry: One hundred and fourty-six preparative examples are given. Characterization is by mp, NMR, optical rotation and elemental analysis.

Structure:

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