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Summary
Novelty: Novel fungicidal compositions comprising a pyranyl ester and a β-lactone are disclosed. A method for controlling mycotic infections is also given.
Biology: The MIC against Candida albicans was determined to be 3.1μg/ml for β-lactone dienoic acid and 2μg/ml for the pyranyl glycine ester.
Chemistry: The pyranyl glycine esters are either (2,3,4,5)-tetrahydro-4-methoxy-5-methyl-2-(1-methyl-1,3,5-nonatrienyl)-2-pyran-3-yl glycine or (2,3,4,5)-tetarahydro-4-methoxy-5-methyl-2-(1-methyl-1,3,5-nonatrienyl)-2-pyran-3-yl-N,N-dimethylglycine. The preferred β-lactone is 11-(3-hydroxymethyl-4-oxo-2-oxetanyl)-7-methyl-2,4-undecadienoic acid.
Structure: 