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Summary
Novelty: A synergistic combination of certain antibodies, which may be directed against the V3 loop and CD-4 binding site of HIV-envelope glycoprotein gp120, is claimed. Antibodies that are able to neutralize the IIIB, MN, SF-1 and RF strains are disclosed. The antibody combinations may be used for the treatment or prevention of HIV infection. Screening methods using the antibodies, vaccines and assay kits are also included.
Biology: Isolation and characterization of chimpanzee anti-V3 antibodies animal serum hyperimmunized with the V3 peptide, was carried out. The assignment of epitopes is shown to correlate with the observation that chimpanzee anti-V3 antibodies are strain-specific, whereas the anti-V3 human monoclonal antibody, 4117CL, recognized a variety of divergent HIV-1 strains.