![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Summary
Novelty: A novel series of vinylogous hydroxamic acids are claimed along with their methods of preparation and their use in the treatment of inflammatory diseases, such as rheumatoid arthritis and psoriasis.
Biology: Data are given for nineteen compounds in a RBL-1 5-lipoxygenase assay with IC50s in the range 0.06–7.7 μM. The most potent compound is said to be 1-(4-biphenyl)-3-(N-hydroxy-N-methyl)aminoprop-2-en-1-one.
Chemistry: Experimental details and physical data are given for twenty-nine examples with the preferred compounds having the aromatic ring substituted with a halogen, nitro or phenyl group. No compounds are specifically claimed.
Structure: