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Summary
Novelty: Novel propanolamine and propylamine derivatives are claimed to be Class III antiarrhythmic agents.
Biology: An in vivo canine study of antiarrhythmic activity is described. Class III antiarrhythmic activity was defined as an increase in ERP (effective refractory period) without a significant decrease in CT (conduction time). Preferred compounds were found to have an effective dose range of 1–5 mg/kg (iv).
Chemistry: 1-[(1H-Benzimidazol-2-ylmethyl)methylamino]-3-(4-nitrophenoxy)-2-propanol dihydrochloride is one of eleven specifically claimed compounds. Preparative details using standard techniques are presented.
Structure: