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Novelty: Novel substituted imidazoles are claimed to inhibit the action of the hormone angiotensin II and therefore are potentially useful as antihypertensive agents.
Biology: No biological data are disclosed.
Chemistry: Eighty-two compounds are exemplified by synthesis; synthesis was by standard techniques. 2-Butyl-1-[[1-[2-(2H-tetrazol-5-yl)phenyl]-1H-indol-4-yl]methyl]-4-(trifluoromethyl)-1H-imidazole-5-carboxylic acid is typical of the claim.
Structure:
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