Quinazolin-4(3H)-ones capable of upregulating the expression of endogenous apolipoprotein A-1

Abstract

An application claims non-naturally occurring upregulators of apolipoprotein A-I (ApoA-l) quinazolin-4(3H)-ones. The claimed quinazolin-4(3H)-ones are efficacious in upregulating the expression of endogeneous ApoA-l, and can potentially treat and prevent cardiovascular disease and related disease states, including cholesterol or lipid-related disorders, such as atherosclerosis. This application of Resverlogix Corp. increases the diversity of quinazolin-4(3H)-ones capable of upregulating the expression of endogeneous ApoA-l.

Keywords::

• anti-atherogenic effect
• apolipoprotein A-I
• cardiovascular disease
• quinazolin-4(3H)-one
• upregulators

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