Aryl amide derivatives of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives useful as ASK1 inhibitors, an evaluation of WO2012080735

Abstract

Novel 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives and their salts, compositions containing them and their use as ASK1 inhibitors in the treatment of inflammation and pain are claimed. The compounds have a broad potential utility with osteoarthritis and neuropathic pain among the likely preferred indications.

Keywords::

• apoptosis
• ASK1
• ASK1 inhibitor
• inflammation
• neuropathic pain
• osteoarthritis
• pain