Abstract
Novelty: Amphiphilic peptides (ion channel-forming peptides) are claimed as antibiotics. They may be used to inhibit or prevent growth of microbial and other infections. They can be used in combination with various antibiotic agents.
Biology: Antibacterial activity of nine peptides was assayed against three bacterial cultures. MIC values were 4 to > 256 μg/ml for S. aureus, 4 to 256 μg/ml for E. aeruginosa, and 4 to 256 μ/ml for E. coli. Bacterial cell concentrations were 1-5 × 105 CFUs/ml. MIC for the preferred peptide was 4, 8 and 32 μg/ml, for the microorganisms, respectively.
Chemistry: The peptides may be produced by standard techniques such as solid protein synthesis or genetic manipulation and obtained in substantially pure form. DNA encoding the proteins may also be provided and expressed from suitable organisms. The preferred peptide comprises 16 amino acids.