Xanthofulvin as an inhibitor of chitin synthase and its potential as an antifungal: Current Opinion on Therapeutic Patents: Vol 3, No 12

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Patent Summary

A novel antifungal agent, Xanthofulvin, is claimed. It is obtained from cultures of Eupenicillium sp.

Inhibitory activity against Cus 1 and Cus 2 (from Saccharomyces cerevisiae) was determined using [¹⁴C]-UDP-N-acetylglucosamine. IC₅₀ values were 7200 and 2.2 μM, respectively.

Fermentation methods of Eupenicillium sp. NR7125 and subsequent isolation of Xanthofulvin are described. Physicochemical properties are also given.

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