Patent Evaluation : W09300923-: Choudhq;C.: Isolation of a novel T cell colony stimulating factor for treatment of immunocompromised patients

Abstract

Novelty: A purified and isolated nucleic acid encoding a novel T cell colony stimulating factor (TC-CSF) is claimed. Haematopoietic growth factors may be useful for treating immune-compromised patients, including AIDS patients and patients with certain types of cancer.

Biology: TC-CSF stimulates formation of colonies composed of granulocytes, macrophages, megakaryocytes, fibrocytic stromal cells, lymphocytes, and mixed colonies of granulocytes and macrophages. Human TC-CSF and murine TC-CSF cDNA, mRNA, genomic DNA nucleotide and amino acid sequences, expression products, pharmaceutical formulations and antibody materials are described.

Chemistry: Anion exchange chromatography may be employed in conjunction with gel filtration and reverse phase high pressure liquid chromatography (HPLC) to isolate TC-CSF.