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Summary
Novelty: The use of melatonin derivatives for the treatment of hormonally dependent breast carcinoma is claimed. Compositions containing these compounds together with an anti-oestrogen compound are also claimed.
Biology: The effect of melatonin derivatives on the size of DMBA-induced mammary tumours in femal SD rats was measured. Results obtained over 3–5 weeks are presented in tables and show a reduction in tumour size for the compounds administered (po), compared to vehicle alone. The effect of co-administration of tamoxifen is also presented.
Chemistry: Three melatonin derivatives specifically claimed are β-methyl-6-chloro-melatonin, 2-methyl-6,7-dichloromelatonin and β-methyl-6-fluoromelatonin. A combination of β-methyl-6-chloromelatonin and tamoxifen is especially preferred.