Summary
Novelty: Novel immunotoxins containing the MAB B3 antibody (found on the surface of many mucinous carcinomas of the colon, stomach, ovaries and breasts) are claimed. Recombinant processes for producing these immunotoxins are also claimed.
Biology: The B3 immunotoxins were tested on A431 epidermoid cells in vitro. The two new immunotoxins gave ID50 values of 50pM and 13pM.
Chemistry: Full recombinant details are presented.