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Summary
Novelty: 4-Alkyl-1,4-dihydropyridines are claimed as PAF antagonists for the treatment of inflammatory processes, psoriasis, glomerulonephritis, transplant rejection, bronchitis, asthma and allergy. They are also claimed to stimulate cellular immunity and for the treatment of immunodeficient syndromes. A method for preparation of the compounds is also disclosed.
Biology: Platelet aggregation induced by 1-PAF was measured using platelet rich plasma from rabbits. The specified compound gave an IC50 value of 0.15 μM. Results for thirty-five compounds were 0.15-10 μM.
Chemistry: The preparation of over one hundred and seventy compounds is exemplified and the method forms a subsidiary part of the claim. No compounds are specifically claimed.