Phenyl acetic acid derivatives as inhibitors of leukotriene synthesis

Abstract

The preparation of arylmethoxysubstitutedphenyl acetic acid derivatives and their use as effective agents to inhibit leukotrienes are claimed. The three patent applications cover related compounds in a series of inhibitors that has been well studied by Bayer [1]. The compounds are stated to be useful in treating several diseases of allergy and inflammation that are often associated with leukotrienes. Biological data are limited to inhibition of LTB₄ in calcium ionophore stimulated human PMNL and is included for only a few selected compounds. Most of the synthetic chemistry used for their preparation is standard, however, some methodology has been developed for the introduction of substituents on the central phenyl ring.