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Abstract
The patents under review cover a series of morpholi-nes and thiomorpholines, substituted with a 2-benzy-loxy group and a 3-phenyl group, as tachykinin receptor antagonists for the treatment of pain and inflammation. This series is distinguished from a number of similar structural series which have recently been claimed as tachykinin receptor antagonists, by their cyclic acetyl structure. Compound 1, the S isomer, is specified in EP-577394 [101]; it is readily formed and is surprisingly chemically stable.