Overview Cardiovascular & Renal: Angiotensin antagonists: agents that interact with the AT2 receptor and their potential therapeutic utilities

Abstract

The primary and patent literature (through mid-1994) describing advances in AT₂ receptor molecular biology and agents that interact with the angiotensin AT₂ receptor subtype is reviewed. In vitro structure-activity relationships are summarised for both AT₂-specific antagonists and balanced AT₁/AT₂ antagonists. Literature reports describing functional correlates for AT₂ receptors are tabulated, and potential therapeutic utilities resulting from pharmacological intervention at AT₂ receptors are discussed.