Anti-infectives: Antibody treatment of Helicobacter pylori

Abstract

In this Galagen application, antibodies have been developed for the urease enzyme associated with Helicobacter pylori. The antibodies are reported to prevent, inhibit or retard growth of H. pylori colonies in the gastrointestinal tract. The antibodies were derived from Jack Bean or H. pylori ureases by immunisation of a mammal, e.g., rabbit or cow. The antibody inhibits the activity of the urease enzyme associated with H. pylori that catalyses the hydrolysis of urea in the gastric juices to carbon dioxide and ammonia. The same antibodies can be used as a diagnostic test for H. pylori infection.