Cell-matrix adhesive proteins: further therapeutic applications

Abstract

Cell-matrix adhesive proteins are specialised extracellular molecules frequently found surrounding cells as a bridge between cell-membrane receptors (normally integrins) and the structural extracellular matrix. These macromolecules can act as pivotal controllers of cell function and cell selection and have attracted considerable interest as points of possible therapeutic intervention. Recent applications have centred around either supplementing their activity (at sites of deficiency or in biomaterials/tissue engineering) or inhibiting their activity, to reduce binding of cells implicated in inflammation, metastasis, thrombosis or infection. Both competitive peptide sequences and more conventional pharmaceutical agents, with inhibitory activity, have been identified.