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Research

Overview Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis Recent advances in leukotriene B4 receptor antagonist research

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Pages 21-28 | Published online: 29 Feb 2008
 

Abstract

Leukotriene B4 (LTB4), a product of the arachidonic acid cascade, has been shown to be an important modulator of inflammatory cell function, the overproduction of which is believed to potentiate the tissue damage seen in many inflammatory diseases where medical needs remain unmet. Several antagonists of the LTB4 receptor are poised for clinical trial and a new spate of third generation compounds has been revealed in the recent patent literature.

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